ブックタイトル教育医学 J.Educ.Health Sci.　第63巻　第3号　通巻 第289号

概要

教育医学 J.Educ.Health Sci.　第63巻　第3号　通巻 第289号

Tatsuya USUI, Shintaro TSUJI, Nobuhito NAGAI and Chie TAKEYASU21）Hosokawa I, Hosokawa Y, Komatsuzawa H,Goncalves RB, Karimbux N, Napimoga MH,Seki M, Ouhara K, Sugai M, Taubman MAand Kawai T (2006) Innate immune peptideLL-37 displays distinct expression patternfrom beta-defensins in inflamed gingivaltissue. Clin Exp Immunol, 146, 218-25.22）Kirschbaum C and Hellhammer DH (1994)Salivary cortisol in psychoneuroendocrineresearch: recent developments and applications.Psychoneuroendocrinology, 19, 313-33.23）Levine A, Zagoory-Sharon O, Feldman R,Lewis JG and Weller A(2007) Measuringcortisol in human psychobiological studies.Physiol Behav, 90, 43-53.24）Lowry OH, Rosebrough NJ, Farr AL and RandallRJ (1951) Protein measurement with the Folinphenol reagent. J Biol Chem, 193, 265-75.25）MacKinnon LT and Jenkins DG (1993)Decreased salivary immunoglobulins afterintense interval exercise before and aftertraining. Med Sci Sports Exerc, 25, 678-83.26）Murakami M, Ohtake T, Dorschner RA andGallo RL (2002) Cathelicidin antimicrobialpeptides are expressed in salivary glands andsaliva. J Dent Res, 81, 845-50.27）Nieman DC(1995) Upper respiratory tractinfections and exercise. Thorax, 50, 1229-31.28）Nijnik A and Hancock RE (2009) The rolesof cathelicidin LL-37 in immune defencesand novel clinical applications. Curr OpinHematol, 16, 41-7.29）Sari-Sarraf V, Reilly T, Doran DA andAtkinson G (2007) The effects of single andrepeated bouts of soccer-specific exercise onsalivary IgA. Arch Oral Biol, 52, 526-32.30）Sari-Sarraf V, Reilly T and Doran DA (2006)Salivary IgA response to intermittent andcontinuous exercise. Int J Sports Med, 27,849-55.31）Saxon A, Stevens RH, Ramer SJ, ClementsPJ and Yu DT (1978) Glucocorticoidsadministered in vivo inhibit humansuppressor T lymphocyte function anddiminish B lymphocyte responsiveness inin vitro immunoglobulin synthesis. J ClinInvest, 61, 922-30.32）Singh PK, Jia HP, Wiles K, Hesselberth J, LiuL, Conway BA, Greenberg EP, Valore EV,Welsh MJ, Ganz T, Tack BF and McCrayPB Jr (1998) Production of beta-defensins byhuman airway epithelia. Proc Natl Acad SciU S A, 95, 14961-6.33）Strazdins L, Meyerkort S, Brent V, D'SouzaRM, Broom DH and Kyd JM (2005) Impact ofsaliva collection methods on sIgA and cortisolassays and acceptability to participants. JImmunol Methods, 307, 167-71.34）Ueda SY, Yoshikawa T, Katsura Y, Usui Tand Fujimoto S (2009) Comparable effectsof moderate intensity exercise on changesin anorectic gut hormone levels and energyintake to high intensity exercise. J Endocrinol,203, 357-64.35）van Eck M, Berkhof H, Nicolson N and SulonJ (1996) The effects of perceived stress, traits,mood states, and stressful daily events onsalivary cortisol. Psychosom Med, 58, 447-58.36）Vardar-Sengul S, Demirci T, Sen BH, ErkizanV, Kurulgan E and Baylas H (2007) Humanbeta defensin-1 and -2 expression in thegingiva of patients with specific periodontaldiseases. J Periodontal Res, 42, 429-37.37）Witko-Sarsat V, Rieu P, Descamps-LatschaB, Lesavre P and Halbwachs-Mecarelli L(2000) Neutrophils: molecules, functions andpathophysiological aspects. Lab Invest, 80,617-53.38）Yang D, Biragyn A, Hoover DM, LubkowskiJ and Oppenheim JJ (2004) Multiple rolesof antimicrobial defensins, cathelicidins,and eosinophil-derived neurotoxin in hostdefense. Annu Rev Immunol, 22, 181-215.FIGURE LEGENDSFIGURE 1 Scheme of the present studyFIGURE 2 Association of increases in saliva cortisolconcentrations (ΔAUCcortisol) with those in salivaconcentrations of HBD-2 (ΔAUCHBD-2) (A) and LL-37(ΔAUCLL-37) (B)FIGURE 3 Association of increases in plasmanorepinephrine concentrations (ΔAUCnorepinephrine) withthose in saliva concentrations of HBD-2 (ΔAUCHBD-2)(A) and LL-37 (ΔAUCLL-37) (B)（受付：2017年4月14日）（受理：2017年10月17日）? 239 ?