ブックタイトル教育医学 J.Educ.Health Sci.　第63巻　第3号　通巻 第289号

概要

教育医学 J.Educ.Health Sci.　第63巻　第3号　通巻 第289号

Change in Oral Antimicrobial Peptides and Neuroendocrine Response by Intense Exercisemight affect individual immune componentsvia activity of the HPA axis, resulting in partialalterations in oral immunity and giving rise toadditional stress by infectious illness.Ⅴ．Acknowledgements and Conflictof interest statementThe authors thank all volunteers for theirparticipation in the present study. None of theauthors have a financial relationship with anycommercial entity that has an interest in the subjectof this manuscript.Reference1）Aberg KM, Radek KA, Choi EH, Kim DK,Demerjian M, Hupe M, Kerbleski J, Gallo RL,Ganz T, Mauro T, Feingold KR and Elias PM(2007) Psychological stress downregulatesepidermal antimicrobial peptide expressionand increases severity of cutaneous infectionsin mice. J Clin Invest, 117, 3339-49.2）Akimoto T, Kumai Y, Akama T, HayashiE, Murakami H, Soma R, Kuno S and KonoI (2003) Effects of 12 months of exercisetraining on salivary secretory IgA levels inelderly subjects. Br J Sports Med, 37, 76-9.3）Allgrove JE, Gomes E, Hough J and GleesonM (2008) Effects of exercise intensity onsalivary antimicrobial proteins and markers ofstress in active men. J Sports Sci, 26, 653-61.4）Beisswenger C, Kandler K, Hess C, GarnH, Felgentreff K, Wegmann M, Renz H,Vogelmeier C and Bals R (2006) Allergic airwayinflammation inhibits pulmonary antibacterialhost defense. J Immunol, 177, 1833-7.5）Bishop NC and Gleeson M (2009) Acuteand chronic effects of exercise on markers ofmucosal immunity. Front Biosci, 14, 4444-56.6）Bishop NC, Walker GJ, Scanlon GA,Richards S and Rogers E (2006) Salivary IgAresponses to prolonged intensive exercisefollowing caffeine ingestion. Med Sci SportsExerc, 38, 513-9.7）Bonass WA, High AS, Owen PJ and DevineDA (1999) Expression of beta-defensin genesby human salivary glands. Oral MicrobiolImmunol. 14, 371-4.8）Chrousos GP and Gold PW (1992) Theconcepts of stress and stress system disorders.Overview of physical and behavioralhomeostasis. JAMA, 267, 1244-52.9）Chrousos GP and Kino T (2007) Glucocorticoidaction networks and complex psychiatric and/or somatic disorders. Stress, 10, 213-9.10）Chrousos GP (1998) Stressors, stress, andneuroendocrine integration of the adaptiveresponse. The 1997 Hans Selye MemorialLecture. Ann N Y Acad Sci, 851, 311-35.11）Davison G, Allgrove J and Gleeson M (2009)Salivary antimicrobial peptides (LL-37 andalpha-defensins HNP1-3), antimicrobial andIgA responses to prolonged exercise. Eur JAppl Physiol, 106, 277-84.12）de Vries WR, Bernards NT, de Rooij MH andKoppeschaar HP (2000) Dynamic exercisediscloses different time-related responses instress hormones. Psychosom Med, 62, 866-72.13）Diamond G, Beckloff N and Ryan LK (2008)Host defense peptides in the oral cavity andthe lung: similarities and differences. J DentRes, 87, 915-27.14）Diamond G, Legarda D and Ryan LK (2000)The innate immune response of the respiratoryepithelium. Immunol Rev, 173, 27-38.15）Dimitriou L, Sharp NC and Doherty M (2002)Circadian effects on the acute responsesof salivary cortisol and IgA in well trainedswimmers. Br J Sports Med, 36, 260-4.16）Doss M, White MR, Tecle T and HartshornKL(2010) Human defensins and LL-37 inmucosal immunity. J Leukoc Biol, 87, 79-92.17）Fleshner M (2000) Exercise and neuroendocrineregulation of antibody production: protectiveeffect of physical activity on stress-inducedsuppression of the specific antibody response.Int J Sports Med, 21 S1, S14-9.18）Gleeson M (2007) Immune function in sportand exercise. J Appl Physiol, 103, 693-9.19）Hancock RE and Diamond G (2008) The roleof cationic antimicrobial peptides in innatehost defences. Trends Microbiol, 8, 402-10.20）Herr C, Beisswenger C, Hess C, Kandler K,Suttorp N, Welte T, Schroeder JM and VogelmeierC (2009) Suppression of pulmonary innate hostdefence in smokers. Thorax, 64, 144-9.? 238 ?