ブックタイトル教育医学 J.Educ.Health Sci.　第63巻　第3号　通巻 第289号

概要

教育医学 J.Educ.Health Sci.　第63巻　第3号　通巻 第289号

Tatsuya USUI, Shintaro TSUJI, Nobuhito NAGAI and Chie TAKEYASU（A）ΔAUC HBD-2 (pg/ml×180min)40,00030,00020,00010,0000r=-0.859p＜0.010 200 400 600 800 1,000（B）ΔAUC LL-37 (ng/ml×180min)2,5002,0001,5001,0005000r=-0.838p＜0.010 200 400 600 800 1,000ΔAUC cortisol (ng/ml×180min)ΔAUC cortisol (ng/ml×180min)FIGURE 2 Association of increases in saliva cortisol concentrations (ΔAUCcortisol) with those in salivaconcentrations of HBD-2 (ΔAUCHBD-2) (A) and LL-37 (ΔAUCLL-37) (B)（A）ΔAUC HBD-2 (pg/ml×180min)40,00030,00020,00010,000r=0.854p＜0.0500.0 0.5 1.0 1.5 2.0 2.5ΔAUC norepinephrine (ng/ml×180min)（B）ΔAUC LL-37 (ng/ml×180min)2,5002,0001,5001,000500r=0.880p＜0.0100.0 0.5 1.0 1.5 2.0 2.5ΔAUC norepinephrine (ng/ml×180min)FIGURE 3 Association of increases in plasma norepinephrine concentrations (ΔAUCnorepinephrine) withthose in saliva concentrations of HBD-2 (ΔAUCHBD-2) (A) and LL-37 (ΔAUCLL-37) (B)immune components, including IgA, HBD-2, andLL-37, in young adult subjects, and to investigatethe association of these acute changes with thosein physical and mental stress parameters, plasmalevels of norepinephrine, and saliva levels ofcortisol. The present study has revealed thefollowing evidence: 1) A single bout of strenuousexercise (75%・VO2max for 60 min) caused atransient increase in the salivary levels of HBD-2 and LL-37 compared with those in the restingsession, whereas salivary IgA levels significantlydecreased after exercise. 2) In parallel with thesechanges, significant increases were observed in allof the plasma and salivary stress parameters. 3) Ofparticular interest is that, when assessed by AUC,the transient rises in both salivary antimicrobialpeptide levels were negatively correlated withincreases in salivary cortisol levels, while theywere positively associated with those in plasmanorepinephrine levels. In contrast, decreasesin salivary IgA levels were not associated withchanges in any parameters examined. In the presentstudy, the relationship between salivary immuneand stress response substances and exercise(stress) stimuli is investigated using the area underthe curve (AUC) to evaluate stimulus responsesover time. To examine stimulus responses andtemporal effects, salivary and endocrine markersare generally employed. Thus, the relationship canbe examined using the AUC in consideration of? 235 ?